1: 2-(3-bromo-1H-pyrazol-1-yl)-3-chloro-pyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: carbon dioxide in tetrahydrofuran Further stages.;

1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.25 h; 2: in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C; 1 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;

1: phosphorus oxytribromide / acetonitrile / 80 °C 2: dipotassium peroxodisulfate; sulfuric acid / water; acetonitrile / Reflux 3: sodium hydroxide / methanol; water View Scheme

1.1: sodium ethanolate / ethanol / 0.17 h / |Reflux 1.2: 0.5 h / |Reflux 2.1: phosphorus oxytribromide / acetonitrile / 5 h / |Reflux 3.1: sulfuric acid; dipotassium peroxodisulfate / acetonitrile / 4.5 h / |Reflux 4.1: sodium hydroxide; water / methanol / 6 h / 20 °C View Scheme

1: dipotassium peroxodisulfate; sulfuric acid / water; acetonitrile / Reflux 2: sodium hydroxide / methanol; water View Scheme

1.1: NH2NH2•xH2O / ethanol / 36 h / |Reflux 2.1: sodium ethanolate / ethanol / 0.17 h / |Reflux 2.2: 0.5 h / |Reflux 3.1: phosphorus oxytribromide / acetonitrile / 5 h / |Reflux 4.1: sulfuric acid; dipotassium peroxodisulfate / acetonitrile / 4.5 h / |Reflux 5.1: sodium hydroxide; water / methanol / 6 h / 20 °C View Scheme

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