反应条件
1.1: 88 percent / LiOH*H2O; MS 4 Angstroem / tetrahydrofuran / 12 h / Heating
2.1: 90 percent / DIBAL-H / CH2Cl2 / 2 h / -78 - 20 °C
3.1: NaH / (nBu)4NI / tetrahydrofuran / 12 h / 20 °C
4.1: Et3Al; Fe(acac)3; DMO / toluene / 3 h / 55 °C
4.2: PPTS / CH2Cl2 / 12 h / 20 °C
5.1: O3; Ph3P / CH2Cl2
6.1: NaBH4 / methanol
7.1: AcOH / H2O / 75 °C
8.1: PCC / CH2Cl2
9.1: LDA / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
10.1: 85 percent / DDQ / CH2Cl2; H2O
11.1: BF3*OEt2; 4 Angstroem MS / CH2Cl2 / 3 h / -20 °C
12.1: 85 percent / H2 / Pd/C / ethyl acetate; methanol
View Scheme
参考文献
Takacs, James M.; Vayalakkada, Suresh; Mehrman, Steven J.; Kingsbury, Celia L.
Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8417 - 8420
