反应条件
1: (cyanomethyl)triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran T=5 - 20°C; 1 h; 2: 4-[4-(4-formyl-2,6-dimethylphenylamino)pyrimidin-2-ylamino]benzonitrile in tetrahydrofuran T=20°C; Wittig reaction; 8 h;
参考文献
Guillemont, Jerome; Pasquier, Elisabeth; Palandjian, Patrice; Vernier, Daniel; Gaurrand, Sandrine; Lewi, Paul J.; Heeres, Jan; De Jonge, Marc R.; Koymans, Lucien M. H.; Daeyaert, Frits F. D.; Vinkers, Maarten H.; Arnold, Eddy; Das, Kalyan; Pauwels, Rudi; Andries, Koen; De Bethune, Marie-Pierre; Bettens, Eva; Hertogs, Kurt; Wigerinck, Piet; Timmerman, Philip; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2072 - 2079