2-氨基-4,5-二甲氧基苯甲酰胺合成路线 （共 17 条）
反应条件
1: hydrogenchloride / water 2: ammonia View Scheme
参考文献
Yadav; Naik; Gandhi; Chauhan; Giridhar
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
反应条件
formic acid Heating / reflux;
参考文献
Parker Hughes Institute
Patent: US6358962 B2, 2002 ;
Location in patent: Example 1 ;
参考文献
Trieu, Vuong N.; Liu, Xing-Ping; Chen, Chun-Lin; Uckun, Fatih M.
Journal of Cardiovascular Pharmacology, 2000 , vol. 35, # 2 p. 179 - 188
反应条件
1: Heating 2: POCl2 / Heating View Scheme
参考文献
Trieu, Vuong N.; Liu, Xing-Ping; Chen, Chun-Lin; Uckun, Fatih M.
Journal of Cardiovascular Pharmacology, 2000 , vol. 35, # 2 p. 179 - 188
反应条件
hydrogenchloride in water
参考文献
Yadav; Naik; Gandhi; Chauhan; Giridhar
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966
反应条件
1: 1.18 g / 5 h / Heating 2: 83 percent / phosphorus oxychloride / 4 h / Heating 3: 84.29 percent / Et3N / methanol / Heating View Scheme
参考文献
Trieu, Vuong N.; Liu, Xing-Ping; Chen, Chun-Lin; Uckun, Fatih M.
Journal of Cardiovascular Pharmacology, 2000 , vol. 35, # 2 p. 179 - 188
反应条件
hydrogen; palladium on activated charcoal in methanol
P=2585.81 Torr; 20 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
Location in patent: Paragraph 0525; 0526 ;
反应条件
1: SOCl2
2: NH4OH
3: NaBH4 / CuSO4
View Scheme
参考文献
Uckun, Fatih M.; D'Cruz, Osmond J.; Liu, Xing-Ping; Narla, Rama Krishna
Arzneimittel-Forschung/Drug Research, 2003 , vol. 53, # 6 p. 428 - 439
反应条件
sodium tetrahydroborate; copper(II) sulfate in methanol
参考文献
Hughes Institute
Patent: US6172071 B2, 2001 ;
