Alpha-苯基-2-吡啶基乙腈合成路线 （共 23 条）
反应条件
sodium amide in toluene T=0 - 30°C; 17 h;
参考文献
Celgene Corporation
Patent: US6359139 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
in ethyl acetate; toluene
参考文献
Celgene Corporation
Patent: US5936091 A1, 1999 ;
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=110°C; 0.0166667 h; microwave irradiation;
参考文献
Cherng, Yie-Jia
Tetrahedron, 2002 , vol. 58, # 24 p. 4931 - 4935
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=110°C; 0.0166667 h; microwave irradiation;
参考文献
Cherng, Yie-Jia
Tetrahedron, 2002 , vol. 58, # 24 p. 4931 - 4935
反应条件
potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=110°C; 0.0166667 h; microwave irradiation;
参考文献
Cherng, Yie-Jia
Tetrahedron, 2002 , vol. 58, # 24 p. 4931 - 4935
反应条件
KNH2 in ammonia 0.25 h; Irradiation;
参考文献
Carver, David R.; Greenwood, Thomas D.; Hubbard, James S.; Komin, Andrew P.; Sachdeva, Yesh P.; Wolfe, James F.
Journal of Organic Chemistry, 1983 , vol. 48, # 8 p. 1180 - 1185
反应条件
sodium hydride in tetrahydrofuran Heatingvar. methoxy-N-heteroaromatics; Product distribution;
参考文献
Yamanaka, Hiroshi; Ohba, Setsuya
Heterocycles, 1990 , vol. 31, # 5 p. 895 - 909
反应条件
ammonia; potassium; iron nitrate (III) 1.) 30 min, 2.) ether, irradiated 1.5h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hermann, Christine K. F.; Sachdeva, Yesh P.; Wolfe, James F.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1061 - 1065
反应条件
sodium amide; toluene
参考文献
Panizzon
Helvetica Chimica Acta, 1944 , vol. 27, p. 1748,1753
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Sury; Hoffmann
Helvetica Chimica Acta, 1954 , vol. 37, p. 2133,2141
Helvetica Chimica Acta, 1955 , vol. 38, p. 728,735
反应条件
n-butyllithium; 2-bromo-2-methylpropiophenon 1.) THF, liquid N2, 2.9 r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Werry, Juergen; Stamm, Helmut; Sommer, Andreas
Chemische Berichte, 1990 , vol. 123, # 7 p. 1553 - 1562
