Alpha-苯基-2-吡啶基乙腈合成路线 （共 23 条）
反应条件
n-butyllithium 1.) THF, liquid N2, 2.) r.t., 24 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Werry, Juergen; Stamm, Helmut; Sommer, Andreas
Chemische Berichte, 1990 , vol. 123, # 7 p. 1553 - 1562
反应条件
sodium amide; toluene anschl. mit <2-Chlor-aethyl>-dimethyl-amin und anschl. Erwaermen mit H2SO4;
参考文献
Klosa
Archiv der Pharmazie (Weinheim, Germany), 1953 , vol. 286, p. 433,436
反应条件
1: With sulfuric acid T=10 - 20°C; 16 h; 2: With sodium hydroxide in water T=10 - 30°C; pH=12;
参考文献
Celgene Corporation
Patent: US6359139 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
sodium hydroxide in water
参考文献
Celgene Corporation
Patent: US5936091 A1, 1999 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene 3 h;
参考文献
Hermann, Christine K. F.; Sachdeva, Yesh P.; Wolfe, James F.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1061 - 1065
反应条件
potassium hydroxide; dimethyl sulfoxide T=50°C; 24 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 11 p. 3067 - 3071
反应条件
potassium hydroxide; dimethyl sulfoxide; 3-chloropropan-1-ol T=50°C; 24 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 11 p. 3067 - 3071
反应条件
potassium hydroxide; 3-chloropropan-1-ol T=50°C; 24 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 11 p. 3067 - 3071
参考文献
Panizzon
Helvetica Chimica Acta, 1944 , vol. 27, p. 1748,1753
参考文献
Panizzon
Helvetica Chimica Acta, 1944 , vol. 27, p. 1748,1753
Full Text Show Details
Klosa
Archiv der Pharmazie (Weinheim, Germany), 1953 , vol. 286, p. 433,436
