反应条件
1.1: pyridine / N,N-dimethyl-formamide / 1 h / 20 °C 2.1: calcium monohydride / 0.5 h / 230 °C / Inert atmosphere 2.2: 1 h / 20 °C 2.3: 1 h / 100 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 65 °C / Inert atmosphere 3.2: 0.17 h View Scheme
参考文献
Qiao, Jennifer X.; Wang, Tammy C.; Ruel, Rejean; Thibeault, Carl; L'Heureux, Alexandre; Schumacher, William A.; Spronk, Steven A.; Hiebert, Sheldon; Bouthillier, Gilles; Lloyd, John; Pi, Zulan; Schnur, Dora M.; Abell, Lynn M.; Hua, Ji; Price, Laura A.; Liu, Eddie; Wu, Qimin; Steinbacher, Thomas E.; Bostwick, Jeffrey S.; Chang, Ming; Zheng, Joanna; Gao, Qi; Ma, Baoqing; McDonnell, Patricia A.; Huang, Christine S.; Rehfuss, Robert; Wexler, Ruth R.; Lam, Patrick Y. S.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9275 - 9295
