4-(氯甲基)-1H-咪唑-1-羧酸叔丁酯合成路线 (共 2 条)
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=0°C;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2009/170907 A1, 2009 ;
Location in patent: Page/Page column 45-46 ;
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide
T=0°C; 0.25 h;
参考文献
Peng, Hairuo; Carrico, Dora; Thai, Van; Blaskovich, Michelle; Bucher, Cynthia; Pusateri, Erin E.; Sebti, Said M.; Hamilton, Andrew D.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 9 p. 1768 - 1784