N-BOC-2-吗啉甲酸甲酯合成路线 （共 4 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 15 h;
参考文献
Ichikawa, Masanori; Ohtsuka, Masami; Ohki, Hitoshi; Haginoya, Noriyasu; Itoh, Masao; Sugita, Kazuyuki; Usui, Hiroyuki; Suzuki, Makoto; Terayama, Koji; Kanda, Akira
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 3072 - 3093
反应条件
1: With lithium borohydride in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran T=20°C; 1 h;
参考文献
WO2004/5295 A1, ;
Page 155-156 ;
反应条件
1: With trifluoroacetic acid in dichloromethane 1.5 h; 2: With ammonia in methanol; dichloromethane
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/28654 A1, 2007 ;
Location in patent: Page/Page column 42-43 ;
WO 2007/028654 A1
反应条件
1: With potassium hydroxide in methanol; water T=20°C; 8 h; 2: With citric acid in methanol; water
参考文献
KYORIN PHARMACEUTICAL CO., LTD.
Patent: EP1780210 A1, 2007 ;
Location in patent: Page/Page column 58 ;
