反应条件
1.1: NaH / dimethylformamide
1.2: 70 percent / aq. NaOH / methanol
2.1: N,O-dimethylhydroxylamine hydrochloride; HOBT; EDAC
2.2: 80 percent / DIBAL / tetrahydrofuran / -78 °C
3.1: 95 percent / CH2Cl2
4.1: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate
5.1: 100 percent / aq. NaOH / methanol
View Scheme
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513