5-(4-硝基苯基)-噻吩并[2,3-d]嘧啶-4-胺合成路线 （共 7 条）
反应条件
triphenylphosphine
T=145 - 150°C; 4.33333 h;
参考文献
Barnes, David M.; Haight, Anthony R.; Hameury, Thomas; McLaughlin, Maureen A.; Mei, Jianzhang; Tedrow, Jason S.; Riva Toma, Joan Dalla
Tetrahedron, 2006 , vol. 62, # 49 p. 11311 - 11319
反应条件
1: 4-nitrophenylacetoaldehyde; malononitrile With ammonium acetate; acetic acid in benzene
18 h; Reflux;
2: With sulfur; triethylamine in tetrahydrofuran; ethanol
T=25°C;
3: formamide T=150 - 160°C; 19 h;
参考文献
Mellican, Sean M.; Linton, Cathie L.; Mei, Jianzhang; Tedrow, Jason S.; Charukamnoetkanok, Nahathai
Patent: US2009/270424 A1, 2009 ;
Location in patent: Page/Page column 3 ;
反应条件
in DMF (N,N-dimethyl-formamide)
T=150 - 160°C; 19 h;
参考文献
Michaelides, Michael R.; Curtin, Michael L.; Dai, Yujia; Davidsen, Steven K.; Frey, Robin R.; Guo, Yan; Ji, Zhiqin
Patent: US2003/225273 A1, 2003 ;
Location in patent: Page 22 ;
反应条件
1: 90 percent / HMDS / acetic acid / 55 °C
2: 80 percent / S8; water; NaHCO3 / tetrahydrofuran / 35 °C
3: 88 percent / 150 °C
View Scheme
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
1: 80 percent / S8; water; NaHCO3 / tetrahydrofuran / 35 °C
2: 88 percent / 150 °C
View Scheme
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
sulfur; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=130°C; 5.5 h;
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
