5-(4-氨基苯基)-噻吩并[2,3-d]嘧啶-4-胺合成路线 （共 5 条）
反应条件
sulfur; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=130°C; 5.5 h;
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
1: T=150°C;
2: With hydrogen; nickel in tetrahydrofuran; methanol
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
1.1: 90 percent / HMDS / acetic acid / 55 °C
2.1: 80 percent / S8; water; NaHCO3 / tetrahydrofuran / 35 °C
3.1: 150 °C
3.2: 76 percent / hydrogen / Raney Ni / methanol; tetrahydrofuran
View Scheme
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
1.1: 80 percent / S8; water; NaHCO3 / tetrahydrofuran / 35 °C
2.1: 150 °C
2.2: 76 percent / hydrogen / Raney Ni / methanol; tetrahydrofuran
View Scheme
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
反应条件
1: 88 percent / 150 °C
2: 93 percent / S8; NaHCO3 / dimethylformamide / 5.5 h / 130 °C
View Scheme
参考文献
McLaughlin, Maureen A.; Barnes, David M.
Tetrahedron Letters, 2006 , vol. 47, # 51 p. 9095 - 9097
