5-溴-3-乙基-2-甲基-1-苯并噻吩合成路线 （共 2 条）
反应条件
1: With hydrazine hydrate in ethylene glycol
T=80°C; 1 h;
2: With potassium hydroxide in ethylene glycol
T=190°C; 6 h;
参考文献
Tatsumi, Ryo; Fujio, Masakazu; Takanashi, Shin-Ichi; Numata, Atsushi; Katayama, Jiro; Satoh, Hiroyuki; Shiigi, Yasuyuki; Maeda, Jun-Ichi; Kuriyama, Makoto; Horikawa, Takashi; Murozono, Takahiro; Hashimoto, Kenji; Tanaka, Hiroshi
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4374 - 4383
反应条件
1.1: AlCl3 / CH2Cl2 / 2 h / 20 °C
2.1: hydrazine monohydrate / ethane-1,2-diol / 1 h / 80 °C
2.2: 2.7 g / KOH / ethane-1,2-diol / 6 h / 190 °C
View Scheme
参考文献
Tatsumi, Ryo; Fujio, Masakazu; Takanashi, Shin-Ichi; Numata, Atsushi; Katayama, Jiro; Satoh, Hiroyuki; Shiigi, Yasuyuki; Maeda, Jun-Ichi; Kuriyama, Makoto; Horikawa, Takashi; Murozono, Takahiro; Hashimoto, Kenji; Tanaka, Hiroshi
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4374 - 4383
