反应条件
1: 99 percent / methanol / Heating 2: 98 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 3: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) -50 deg C 4: DIBAL / tetrahydrofuran; toluene / 2 h / -78 °C 5: 1) Zn-powder, 2) trimethylsilyl chloride / 1) THF, r.t., 15 min, 2) r.t., 45 min 6: 1) Me3OBF4, 2) aq.Na2CO3 / 1) CH2Cl2, r.t., 2 h, 2) 6 h 8: 88.5 percent / p-toluenesulfonic acid / CH2Cl2 / Ambient temperature 9: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature 10: 94 percent / pyridine / CHCl3 / a) 0 deg C, 6 h, b) r.t., overnight 11: 76 percent / LiAlH4 / diethyl ether / 48 h / Heating 12: MeI, CaCO3 / acetonitrile; H2O / 24 h / 35 °C 13: p-toluenesulfonic acid / ethanol / 2 h / 55 °C View Scheme
参考文献
Solladie; Ziani-Cherif
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2181 - 2185
