(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛合成路线 （共 16 条）
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
→
105-92-0(6E,8E,10E,12E,14E,16E,18Z,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-八甲基三十二碳-6,8,10,12,14,16,18,20,22,24,26,30-十二烯-2-醇
反应条件
1: NaOMe / benzene; methanol 2: NaOMe / methanol View Scheme
参考文献
Bonnett,R. et al.
Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 1739 - 1744
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
→
反应条件
1: (i) nBuLi, Ph3P*HBr (ii) /BRN= 1713035/ 2: (i) nBuLi, (ii) /BRN= 6087132/ 3: LiAlH4 View Scheme
参考文献
Kjoesen,H.; Liaaen-Jenssen,S.
Acta Chemica Scandinavica (1947-1973), 1972 , vol. 26, p. 4121 - 4129
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
→
反应条件
1: (i) nBuLi, (ii) /BRN= 1713035/ 2: (i) nBuLi, (ii) /BRN= 4080214/ View Scheme
参考文献
Bonnett,R. et al.
Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 1739 - 1744
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
→
反应条件
1: (i) nBuLi, Et2O, (ii) /BRN= 1713035/, CH2Cl2 2: LiAlH4 View Scheme
参考文献
Aasen,A.J.; Jensen,S.L.
Acta Chemica Scandinavica (1947-1973), 1967 , vol. 21, p. 970 - 982
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
→
141290-91-76,10,15,19-四甲基-4,6,8,10,12,14,16,18,20-二十四壬烯-2,3,22,23-四酮
反应条件
1: KOH / methanol 2: H+ / acetone View Scheme
参考文献
Bettermann, Hans; Bienioschek, Martin; Ippendorf, Hans; Martin, Hans-Dieter
Angewandte Chemie, 1992 , vol. 104, # 8 p. 1073 - 1075
→
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
反应条件
manganese(IV) oxide in dichloromethane
T=20°C; 2 h; Heating / reflux;
参考文献
HAWAII BIOTECH, INC.; LOCKWOOD, Samuel, F.; TANG, Peng, Cho; NADOLSKI, Geoff; FANG, Zhiqiang; DU, Yishu; GEISS, William; WILLIAMS, Richard; BURDICK, William
Patent: WO2006/39685 A2, 2006 ;
Location in patent: Page/Page column 47 ;
→
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
反应条件
1: DIBALH / CH2Cl2 / 0.5 h / -20 °C
2: 0.015 g / MnO2 / CH2Cl2; H2O / 12 h / 20 °C
View Scheme
参考文献
Frederico, Daniel; Marcos Donate, Paulo; Gomes Constantino, Mauricio; Soares Bronze, Erika; Sairre, Mirela I.
Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 9126 - 9128
→
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
反应条件
1: aq. NaOH / methanol
2: PBr3 / dimethylformamide; CH2Cl2
3: CH2Cl2
View Scheme
参考文献
Schwieter,U. et al.
Helvetica Chimica Acta, 1966 , vol. 49, p. 369 - 390
→
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
反应条件
lithium methanolate in methanol; dichloromethane
Wittig olefination;
参考文献
Effenberger; Wezstein
Synthesis, 2001 , # 9 p. 1368 - 1376
→
502-70-5(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-四甲基-2,4,6,8,10,12,14-十六碳七烯二醛
反应条件
1: PBr3 / dimethylformamide; CH2Cl2
2: CH2Cl2
View Scheme
参考文献
Schwieter,U. et al.
Helvetica Chimica Acta, 1966 , vol. 49, p. 369 - 390
