1: Raney nickel; ethanol / 120 °C / 58840.6 Torr / Hydrogenation 2: pyridine View Scheme

1.1: iodine; potassium hydroxide / -5 - 0 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 3.1: methanol; water; sodium hydroxide / 5 h / Reflux 3.2: 1 h / Reflux 4.1: iodine; potassium hydroxide / -5 - 0 °C 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 6.1: methanol; water; sodium hydroxide / 5 h / Reflux 6.2: 1 h / Reflux 7.1: iodine; potassium hydroxide / -5 - 0 °C 8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 9.1: methanol; water; sodium hydroxide / 5 h / Reflux 9.2: 1 h / Reflux View Scheme

暂无反应条件数据

1: With 2-hydroxy-1,3-isoindolinedione; diphenylmethanol; 2,2'-azo-bisisobutyronitrile; oxygen in acetonitrile T=75°C; Baeyer-Villiger oxidation; P=760.051 Torr; 22 h; 2: With hexafluoroisopropyl alcohol; toluene-4-sulfonic acid T=60°C; Baeyer-Villiger oxidation; Inert atmosphere;

1: With 2,2'-azo-bisisobutyronitrile; oxygen; 2-hydroxy-1,3-isoindolinedione in acetonitrile T=75°C; Baeyer-Villiger Oxidation; P=760.051 Torr; 22 h; 2: With hexafluoroisopropyl alcohol; toluene-4-sulfonic acid T=60°C; Baeyer-Villiger Oxidation; 24 h; Product distribution / selectivity;

selenium(IV) oxide

(i) NaBH4, (ii) Ph3PBr2, (iii) H2, NaHCO3, Raney-Ni; Multistep reaction;

1.1: iodine; potassium hydroxide / -5 - 0 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 3.1: methanol; water; sodium hydroxide / 5 h / Reflux 3.2: 1 h / Reflux 4.1: iodine; potassium hydroxide / -5 - 0 °C 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 6.1: methanol; water; sodium hydroxide / 5 h / Reflux 6.2: 1 h / Reflux View Scheme

1.1: iodine; potassium hydroxide / -5 - 0 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 3.1: methanol; water; sodium hydroxide / 5 h / Reflux 3.2: 1 h / Reflux 4.1: iodine; potassium hydroxide / -5 - 0 °C 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 6.1: methanol; water; sodium hydroxide / 5 h / Reflux 6.2: 1 h / Reflux 7.1: iodine; potassium hydroxide / -5 - 0 °C 8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 9.1: methanol; water; sodium hydroxide / 5 h / Reflux 9.2: 1 h / Reflux 10.1: iodine; potassium hydroxide / -5 - 0 °C 11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C 12.1: methanol; water; sodium hydroxide / 5 h / Reflux 12.2: 1 h / Reflux View Scheme

1: Br2 / methanol / 2 h / 15 - 20 °C 2: Na / ethanol / 5 h / Heating View Scheme