2-苯基-1,2,3,4-四氢喹噁啉合成路线 （共 7 条）
反应条件
1: With [{(η5-C5Me5)IrCl}2(μ-Cl)2]; N-(2-aminoethyl)-4-(trifluoromethyl)benzenesulfonamide; sodium formate; sodium acetate; acetic acid in water
T=80°C; pH=4.3; 10 h;
2: With potassium hydroxide in water
regioselective reaction;
参考文献
Tan, Jing; Tang, Weijun; Sun, Yawei; Jiang, Zhen; Chen, Fei; Xu, Lijin; Fan, Qinghua; Xiao, Jianliang
Tetrahedron, 2011 , vol. 67, # 34 p. 6206 - 6213
反应条件
C88H66Cl3Ir2P4(1+)*Cl(1-) in dichloromethane-d2
T=20°C; 1 h; enantioselective reaction;
参考文献
Nagano, Takuto; Iimuro, Atsuhiro; Kita, Yusuke; Mashima, Kazushi; Schwenk, Rino; Togni, Antonio; Ohshima, Takashi
Chemistry--A European Journal, 2012 , vol. 18, # 37 p. 11578 - 11592,15
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
0 deg C, reflux, 24 h;
参考文献
Olagbemiro, T.O.; Nyakutse, C.A.; Lajide, L.; Agho, M.O.; Chukwu, C.E.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 6 p. 473 - 480
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 120 h;
参考文献
McKinney, Andrew M.; Jackson, Kevin R.; Salvatore, Ralph Nicholas; Savrides, Elena-Maria; Edatte, Mary Jane; Gavin, Terrence
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 5 p. 1031 - 1034
反应条件
1: 1.) potassium iodide, anhydrous potassium carbonate; 2.) sodium methoxyde / 1.) acetone, reflux, 12 h; 2.) benzene, reflux, 7 h
2: 65 percent / lithium aluminium hydride / tetrahydrofuran / 0 deg C, reflux, 24 h
View Scheme
参考文献
Olagbemiro, T.O.; Nyakutse, C.A.; Lajide, L.; Agho, M.O.; Chukwu, C.E.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 6 p. 473 - 480
反应条件
1: 1.) potassium iodide, anhydrous potassium carbonate; 2.) sodium methoxyde / 1.) acetone, reflux, 12 h; 2.) benzene, reflux, 7 h
2: 65 percent / lithium aluminium hydride / tetrahydrofuran / 0 deg C, reflux, 24 h
View Scheme
参考文献
Olagbemiro, T.O.; Nyakutse, C.A.; Lajide, L.; Agho, M.O.; Chukwu, C.E.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 6 p. 473 - 480
反应条件
C21H21ClIrNO2 in tetrahydrofuran; 2,2,2-trifluoroethanol
20 h; Inert atmosphere;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
