6-甲氧基-4H-苯并[1,4]恶嗪-3-酮合成路线 （共 14 条）
反应条件
iron; acetic acid T=90°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 79 ;
WO 2006/134378 A1
反应条件
potassium carbonate in acetonitrile 2 h; Heating;
参考文献
Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikstroem, Hakan V; Grol, Cor J
Journal of medicinal chemistry, 2004 , vol. 47, # 22 p. 5451 - 5466
反应条件
iron; acetic acid 2.5 h; Inert atmosphereReflux;
参考文献
Ramesh, Chintakunta; Raju, B. Rama; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa
Tetrahedron, 2011 , vol. 67, # 6 p. 1187 - 1192
反应条件
1: 98 percent / H2 / Pd/C / ethanol / 0.33 h / 20 °C / 1810.02 Torr 2: 87 percent / K2CO3 / acetonitrile / 2 h / Heating View Scheme
参考文献
Journal of medicinal chemistry, , vol. 47, # 22 p. 5451 - 5466
反应条件
1: 64 percent / NaBH4 / 10percent Pd-C / methanol; H2O / 0.25 h 2: 40 percent / 5percent aq. NaCO3 / CH2Cl2 / 0.08 h 3: 45 percent / CF3COOH / benzene / 24 h / Ambient temperature 4: 20percent NaOH / 3 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 11 p. 3891 - 3896
反应条件
sodium hydroxide in ethanol Heating;
参考文献
The Journal of pharmacy and pharmacology, , vol. 22, # 9 p. 684 - 693
反应条件
1: 45 percent / CF3COOH / benzene / 24 h / Ambient temperature 2: 20percent NaOH / 3 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 11 p. 3891 - 3896
反应条件
1: 40 percent / 5percent aq. NaCO3 / CH2Cl2 / 0.08 h 2: 45 percent / CF3COOH / benzene / 24 h / Ambient temperature 3: 20percent NaOH / 3 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 11 p. 3891 - 3896
反应条件
1: Et3N 2: aq. NaOH / ethanol / Heating View Scheme
参考文献
The Journal of pharmacy and pharmacology, , vol. 22, # 9 p. 684 - 693
反应条件
1: 100 mg / 5percent NaOH / 12 h / Ambient temperature 2: 20percent NaOH / 3 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 11 p. 3891 - 3896
