5-溴-6-甲基-1,3-苯并二氧戊环合成路线 （共 7 条）
反应条件
pyridine; bromine in dichloromethane
T=0 - 20°C; 22.5 h;
参考文献
Nishide, Hisaya; Ogawa, Munekazu; Kominami, Hidemasa; Higuchi, Koji; Nishimura, Akihiro
Patent: US2003/216444 A1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
lithium aluminium tetrahydride; bromine in tetrahydrofuran; methanol; chloroform; ethyl acetate
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2004/9995 A1, 2004 ;
反应条件
hydrogenchloride; amalgamated zinc; acetic acid; toluene
参考文献
Tomita et al.
Yakugaku Zasshi, 1952 , vol. 72, p. 384,386
Chem.Abstr., 1953 , p. 7453
反应条件
1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / 70 °C
2.1: dimethyl sulfoxide / 0.33 h / 50 - 90 °C
3.1: water; sodium hydroxide / ethanol / 18 h / Reflux
3.2: pH 2
View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
1: 2-bromo-4,5-methylenedioxytoluene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78°C; 1.16667 h;
3: With water in tetrahydrofuran; hexane
参考文献
Nishide, Hisaya; Ogawa, Munekazu; Kominami, Hidemasa; Higuchi, Koji; Nishimura, Akihiro
Patent: US2003/216444 A1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=70°C; 18 h;
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 18 h / 70 °C
2: dimethyl sulfoxide / 0.33 h / 50 - 90 °C
View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
