2-辛基-1-环丙烯-1-庚酸甲酯合成路线 （共 16 条）
反应条件
1: (i) NaNH2, NH3, (ii) /BRN= 1752112/, THF, 1,2-dimethoxy-ethane, (iii) /BRN= 1098229/, H2SO4
2: (i) Cu, (ii) /BRN= 107654/
3: (i) aq. KOH, nPrOH, (ii) HClO4, Ac2O, (iii) NaBH4, DMSO, (iv) /BRN= 102415/
View Scheme
参考文献
Pawlowski,N.E. et al.
Journal of Organic Chemistry, 1972 , vol. 37, p. 3245 - 3248
反应条件
1: dimethylsulfoxide / 2.5 h / 115 °C
2: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/, ether
3: (i) Cu, (ii) aq. KOH, EtOH
View Scheme
参考文献
Gensler,W.J. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2301 - 2307
反应条件
1: (i) LiNH2, dioxane, (ii) /BRN= 773673/, dioxane
2: dimethylsulfoxide / 2.5 h / 115 °C
3: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/, ether
4: (i) Cu, (ii) aq. KOH, EtOH
View Scheme
参考文献
Gensler,W.J. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2301 - 2307
反应条件
1: dimethylsulfoxide / 1.75 h / Heating
2: (i) SOCl2, ether, (ii) ZnCl2, CH2Cl2, (iii) NaBH4, NaOH, MeOH
3: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/, ether
View Scheme
参考文献
Gensler,W.J. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2301 - 2307
反应条件
1: butyl lithium, HMPA / Ambient temperature
2: aq. NaOH
3: aq. Bu4N(1+)OH(1-) / CH2Cl2
View Scheme
参考文献
Baird, Mark S.; Dale, Cynthia M.; Lytollis, William; Simpson, Michael J.
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1521 - 1522
反应条件
1: butyl lithium, HMPA / Ambient temperature
2: aq. NaOH
3: aq. Bu4N(1+)OH(1-) / CH2Cl2
View Scheme
参考文献
Baird, Mark S.; Dale, Cynthia M.; Lytollis, William; Simpson, Michael J.
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1521 - 1522
反应条件
tetra(n-butyl)ammonium hydroxide in dichloromethane
参考文献
Baird, Mark S.; Dale, Cynthia M.; Lytollis, William; Simpson, Michael J.
Tetrahedron Letters, 1992 , vol. 33, # 11 p. 1521 - 1522
反应条件
1: dimethylsulfoxide / 1.5 h / 90 °C
2: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/, ether
View Scheme
参考文献
Gensler,W.J. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2301 - 2307
反应条件
1: (i) ZnCl2, CH2Cl2, (ii) LiAlH4, ether
2: dimethylsulfoxide / 1.5 h / 90 °C
3: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/, ether
View Scheme
参考文献
Gensler,W.J. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2301 - 2307
反应条件
1: (i) Cu, (ii) /BRN= 107654/
2: (i) aq. KOH, nPrOH, (ii) HClO4, Ac2O, (iii) NaBH4, DMSO, (iv) /BRN= 102415/
View Scheme
参考文献
Pawlowski,N.E. et al.
Journal of Organic Chemistry, 1972 , vol. 37, p. 3245 - 3248
