N-1-Boc-3-苯基哌嗪合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane T=20°C; 1 h;
参考文献
DAC S.r.l.
Patent: EP2133334 A1, 2009 ;
Location in patent: Page/Page column 20 ;
反应条件
1: 75 percent / H2; Pd(OAc)2; AcOH / 4 h / 2585.74 Torr 2: methanol / -78 °C View Scheme
参考文献
Blythin, David J.; Chen, Xiao; Piwinski, John J.; Shih, Neng-Yang; Shue, Ho-Jane; Anthes, John C.; McPhail, Andrew T.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3161 - 3165
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 95 °C
2: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C
View Scheme
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2
