2-(3-碘苯基)乙酸甲酯合成路线 （共 5 条）
反应条件
sulfuric acid
3 h; Reflux;
参考文献
Yu, Gang; Chowdhury, Morshed A.; Abdellatif, Khaled R.A.; Dong, Ying; Praveen Rao; Das, Dipankar; Velazquez, Carlos A.; Suresh, Mavanur R.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 896 - 902
反应条件
sodium iodide; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in tert-butyl alcohol
T=145°C; 1 h; Microwave irradiationInert atmosphere;
参考文献
PROMETIC BIOSCIENCES INC.; GAGNON, Lyne; GROUIX, Brigitte; GEERTS, Lilianne; LAURIN, Pierre; PENNEY, Christopher; ZACHARIE, Boulos
Patent: WO2012/97427 A1, 2012 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1: meta-carboxy iodo-benzene With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=0°C; 0.166667 h;
2: methanol With 4-(N,N-dimethlyamino)pyridine
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87215 A1, 2005 ;
Location in patent: Page/Page column 245 ;
WO 2005/087215 A1
反应条件
in methanol; hexane
T=0°C; Inert atmosphere;
参考文献
Berube, Marie; Poirier, Donald
Canadian Journal of Chemistry, 2009 , vol. 87, # 8 p. 1180 - 1199
反应条件
1: toluene-4-sulfonic acid / 3 h / Reflux
2: sodium iodide; copper(l) iodide; N-methyl-2-(methylamino)ethylamine / tert-butyl alcohol / 1 h / 145 - 150 °C / Inert atmosphere; microwave irradiation
View Scheme
参考文献
PROMETIC BIOSCIENCES INC.; GAGNON, Lyne; GROUIX, Brigitte; GEERTS, Lilianne; LAURIN, Pierre; PENNEY, Christopher; ZACHARIE, Boulos
Patent: WO2012/97427 A1, 2012 ;
