4-氨基-2,4'-二氯二苯甲酮合成路线 （共 7 条）
反应条件
hydrogenchloride; water; iron in ethanol
1 h; Heating / reflux;
参考文献
MEIJI SEIKA KAISHA, LTD.; NIPPON KAYAKU CO., LTD.
Patent: WO2006/13896 A1, 2006 ;
Location in patent: Page/Page column 106-107 ;
反应条件
hydrogenchloride in ethanol; water; ethyl acetate
参考文献
Meiji Seika Kaisha, Ltd.; NIPPON KAYAKU CO., LTD.
Patent: EP1780202 A1, 2007 ;
反应条件
1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h
2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr
View Scheme
参考文献
Carroll; Miller; Mylari; Chappel; Howes Jr.; Lynch; Gupta; Rash; Koch
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 96 - 100
反应条件
1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h
2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr
View Scheme
参考文献
Carroll; Miller; Mylari; Chappel; Howes Jr.; Lynch; Gupta; Rash; Koch
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 96 - 100
反应条件
in sodium carbonate; toluene
参考文献
American Cyanamid Company
Patent: US3988300 A1, 1976 ;
反应条件
in sodium carbonate; toluene
参考文献
American Cyanamid Company
Patent: US3988300 A1, 1976 ;
反应条件
1: 1.) conc. HCl, NaNO2, 2.) NaOAc / 1.) HOAc, H2O, 10 deg C, 30 min, 2.) HOAc, H2O, RT, 1 h
2: NaOAc / acetic acid; H2O / 2 h / 106 °C
3: 50percent H2SO4 / acetic acid; H2O / 2 h / Heating
4: 71 percent / mercaptoacetic acid / propionic acid / 1.3 h / 170 °C
View Scheme
参考文献
Carroll; Miller; Mylari; Chappel; Howes Jr.; Lynch; Gupta; Rash; Koch
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 96 - 100
