tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 1 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1918603', constants.ctx, '0')">dimethylsulfide borane complex</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=20&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: anhydrous xylene / 4 h / |Reflux; |Dean-Stark<br />2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 &deg;C<br />3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / -70 - 20 &deg;C<br />4.1: borane-THF / tetrahydrofuran / 6 h / |Reflux<br />4.2: 2 h / |Reflux<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: xylene / 15 h / Heating<br />2: 83 percent / imidazole / dimethylformamide / 12 h / 25 &deg;C<br />3: 81.7 percent / tetrahydrofuran / 6 h / 0 &deg;C<br />4: 88 percent / BF₃*OEt₂; Et₃SiH / CH₂Cl₂ <br />5: 88 percent / Me₂S*BH₃ / tetrahydrofuran / 20 &deg;C<br /> <br /> &nbsp;