四氢-4-羟基-2H-吡喃-4-甲腈合成路线 (共 5 条)
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; 1,4-dioxane; diethyl ether; water
参考文献
US2009/76062 A1, ;
Page/Page column 22-23 ;
US 20090076062 A1
反应条件
sulfuric acid
T=20°C;
参考文献
Sutin, Lori; Andersson, Soeren; Bergquist, Lars; Castro, Victor M.; Danielsson, Eva; James, Stephen; Henriksson, Martin; Johansson, Lars; Kaiser, Christina; Flyren, Katarina; Williams, Meredith
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4837 - 4840
反应条件
1: ZnI2 / CH2Cl2 / 48 h / Heating
2: 2N aq. HCl / 2 h / Ambient temperature
View Scheme
参考文献
Eiden; Schmidt; Buchborn
Archiv der Pharmazie, 1987 , vol. 320, # 4 p. 348 - 361
反应条件
2Na(2+)*O3S2(2-) in water
参考文献
Kuduk, Scott D.; Chang, Ronald K.; DiPardo, Robert M.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5107 - 5110
反应条件
hydrogenchloride
2 h; Ambient temperature; Yield given;
参考文献
Eiden; Schmidt; Buchborn
Archiv der Pharmazie, 1987 , vol. 320, # 4 p. 348 - 361