N-(3-羟基苯基)-3-氯PIONYL 胺合成路线 （共 3 条）
反应条件
1: With AlCl3, aluminium chloride T=210°C; 0.5 h; 2: With water T=20°C;
参考文献
WYETH
Patent: WO2008/150848 A1, 2008 ;
Location in patent: Page/Page column 132-133 ;
WO 2008/150848 A1
反应条件
1: AlCl3, aluminium chloride / dichloromethane 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 3-amino-phenol With sodium hydride in tetrahydrofuran; mineral oil
6 h; Inert atmosphere;
2: 3-chloropropanoyl chloride in tetrahydrofuran; mineral oil
T=20°C; 6 h; Inert atmosphere;
参考文献
Bodill, Taryn; Conibear, Anne C.; Mutorwa, Marius K.M.; Goble, Jessica L.; Blatch, Gregory L.; Lobb, Kevin A.; Klein, Rosalyn; Kaye, Perry T.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4332 - 4341
