N-乙酰基-DL-烯丙基甘氨酸合成路线 （共 19 条）
反应条件
1: 2-acetylamino-4-pentenoic acid With L-acylase T=65°C; pH=8.0; 2: benzyl chloroformate pH=8.0;
参考文献
Lloyd, Richard C.; Lloyd, Michael C.; Smith, Mark E. B.; Holt, Karen E.; Swift, Jonathan P.; Keene, Philip A.; Taylor, Stephen J. C.; McCague, Raymond
Tetrahedron, 2004 , vol. 60, # 3 p. 717 - 728
反应条件
Multistep reaction.;
参考文献
Tetrahedron, , vol. 60, # 3 p. 717 - 728
反应条件
D-acylase; N-acetyl amino acid racemase G291D/F323Y 18 h; Enzymatic reaction; Reagent/catalyst;
参考文献
Baxter, Scott; Royer, Sylvain; Grogan, Gideon; Brown, Fraser; Holt-Tiffin, Karen E.; Taylor, Ian N.; Fotheringham, Ian G.; Campopiano, Dominic J.
Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19310 - 19313
反应条件
lithium hydroxide T=38°C; 12 h; porcine kidney acylase I;
参考文献
Cox, Russell J.; Sherwin, William A.; Lam, Lister K. P.; Vederas, John C.
Journal of the American Chemical Society, 1996 , vol. 118, # 32 p. 7449 - 7460
反应条件
ammonium hydroxide; CoCl2.6H2O; L-aminoacylase from Aspergillus genus; lithium hydroxide hydrate in water T=37°C; pH=7; 24 h; Resolution of racemateEnzymatic reaction;
参考文献
RSC Advances, , vol. 4, # 5 p. 2482 - 2490
反应条件
1.1: L-acylase / 65 °C / pH 8.0 1.2: 24 percent / pH 8.0 2.1: SOCl2 3.1: lipase AY30 from Candida rugosa 3.2: K2CO3 / methanol 4.1: 83 percent / H2 / Pd/C View Scheme
参考文献
Lloyd, Richard C.; Lloyd, Michael C.; Smith, Mark E. B.; Holt, Karen E.; Swift, Jonathan P.; Keene, Philip A.; Taylor, Stephen J. C.; McCague, Raymond
Tetrahedron, 2004 , vol. 60, # 3 p. 717 - 728
反应条件
ammonium hydroxide; CoCl2.6H2O; L-aminoacylase from Aspergillus genus; lithium hydroxide hydrate in water T=37°C; pH=7; 24 h; Resolution of racemateEnzymatic reaction;
参考文献
Chenault, H. Keith; Dahmer, Juergen; Whitesides, George M.
Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6354 - 6364
反应条件
1: 2-acetylamino-4-pentenoic acid With thermococcus litoralis L-aminoacylase; tris(hydroxymethyl)methylamine hydrochloride T=70°C; pH=8; Resolution of racemateLarge scaleEnzymatic reaction; 2: benzyl chloroformate With sodium hydroxide in tetrahydrofuran; water T=5 - 10°C; pH=7.5 - 8.5; Large scale;
参考文献
Lloyd, Richard C.; Smith, Mark E. B.; Brick, Dean; Taylor, Stephen J. C.; Chaplin, David A.; McCague, Raymond
Organic Process Research and Development, 2002 , vol. 6, # 6 p. 762 - 766
反应条件
1: 2-acetylamino-4-pentenoic acid With L-acylase T=65°C; pH=8.0; 2: benzyl chloroformate pH=8.0;
参考文献
Lloyd, Richard C.; Lloyd, Michael C.; Smith, Mark E. B.; Holt, Karen E.; Swift, Jonathan P.; Keene, Philip A.; Taylor, Stephen J. C.; McCague, Raymond
Tetrahedron, 2004 , vol. 60, # 3 p. 717 - 728
