(+/-)-顺式-12,13-环氧-9(Z)-十八碳烯酸合成路线 （共 3 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water
T=23°C; 6 h;
2: With hydrogenchloride in tetrahydrofuran; water
pH=4.5;
参考文献
Falck; Reddy; Haines, Donovan C.; Reddy, Komandla Malla; Krishna; Graham, Sandra; Murry, Barbara; Peterson, Julian A.
Tetrahedron Letters, 2001 , vol. 42, # 25 p. 4131 - 4133
反应条件
1.1: cytochrome P450BM3, wild type; NADPH; K2CO3 / various solvent(s) / 0.25 h / 20 °C / pH 7.4
1.2: 45 percent / diethyl ether; methanol
2.1: NaOH / tetrahydrofuran; H2O / 6 h / 23 °C
2.2: HCl / tetrahydrofuran; H2O / pH 4.5
View Scheme
参考文献
Falck; Reddy; Haines, Donovan C.; Reddy, Komandla Malla; Krishna; Graham, Sandra; Murry, Barbara; Peterson, Julian A.
Tetrahedron Letters, 2001 , vol. 42, # 25 p. 4131 - 4133
反应条件
1: acetic acid / beim Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge
2: ethanol; aqueous periodic acid
View Scheme
参考文献
Gunstone
Journal of the Chemical Society, 1954 , p. 1611,1616
