1-氯-3-甲基-2-丁烯合成路线 （共 287 条）
反应条件
1: 2-bromo-1-[2-(trimethylsilyl)ethynyl]benzene With n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
2: 1-chloro-3-methyl-2-butene in tetrahydrofuran
T=-78 - 25°C;
参考文献
Madhushaw, Reniguntala J.; Lo, Ching-Yu; Hwang, Chun-Wei; Su, Ming-Der; Shen, Hung-Chin; Pal, Sitaram; Shaikh, Isak R.; Liu, Rai-Shung
Journal of the American Chemical Society, 2004 , vol. 126, # 47 p. 15560 - 15565
反应条件
1.) THF, 6h, 0 deg C, 2.) Ether, reflux, 36h; Yield given. Multistep reaction;
参考文献
Ohga, Kazuya; Yoon, Ung Chan; Mariano, Patrick S.
Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 213 - 219
反应条件
tri-n-butylborane; sec.-butyllithium
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Yoshinori; Yatagai, Hidetaka; Saito, Yoshikazu; Maruyama, Kazuhiro
Journal of Organic Chemistry, 1984 , vol. 49, # 6 p. 1096 - 1104
反应条件
sodium azide in water; acetone
参考文献
Gagneux,A. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 5956 - 5957
反应条件
potassium carbonate in acetonitrile
3 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2008/44041 A1, 2008 ;
Location in patent: Page/Page column 213 ;
参考文献
United Gas Improv.Co.
Patent: US2382031 , 1942 ;
反应条件
silver(I) in tetrahydrofuran
6 h; Ambient temperature;
参考文献
Murai, Toshiaki; Yamamoto, Mikio; Kato, Shinzi
Journal of the Chemical Society, Chemical Communications, 1990 , # 11 p. 789 - 790
反应条件
(i) Mg, Et2O, (ii) /BRN= 878156/; Multistep reaction;
参考文献
Huntsman,W.D. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 1983 - 1988
反应条件
(i) Mg, Et2O, (ii) /BRN= 878156/; Multistep reaction;
参考文献
Huntsman,W.D. et al.
Journal of Organic Chemistry, 1962 , vol. 27, p. 1983 - 1988
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 20 °C / Reflux; Inert atmosphere
1.2: Inert atmosphere
2.1: lithium aluminium tetrahydride / diethyl ether / 0 - 25 °C / Inert atmosphere
View Scheme
参考文献
Gu, Zhenhua; Zakarian, Armen
Organic Letters, 2011 , vol. 13, # 5 p. 1080 - 1082
