1-氯-3-甲基-2-丁烯合成路线 （共 287 条）
参考文献
Martin,M.M.; Gleicher,G.J.
Journal of the American Chemical Society, 1964 , vol. 86, p. 238 - 241
反应条件
ammonium chloride; zinc in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Petrier, Christian; Luche, Jean-Louis
Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 910 - 912
反应条件
1: 22 percent / NaBH4 / ethanol / 2 h / 20 °C
2: 61 percent / benzene / 2 h / 100 °C / Photolysis
View Scheme
参考文献
Yamago, Shigeru; Hashidume, Masahiro; Yoshida, Jun-Ichi
Tetrahedron, 2002 , vol. 58, # 34 p. 6805 - 6813
反应条件
1: 85 percent / 50percent aq. NaOH, tetrabutylammonium iodide / toluene / 4.5 h / 80 °C
2: 83 percent / triphenylphosphine / 3.5 h / 80 °C
3: 49 percent / 98percent formic acid, BF3-ether / 6 h / Heating
View Scheme
参考文献
Mayr, Herbert; Heilmann, Werner; Baeuml, Engelbert; Vorbrueggen, Helmut
Chemische Berichte, 1991 , vol. 124, # 1 p. 203 - 206
反应条件
tetrakis(triphenylphosphine) palladium(0); magnesium in tetrahydrofuran
T=25°C; 0.5 h; Yield given;
参考文献
Veselovskii, A. B.; Filippova, T. M.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 10 p. 2107 - 2110
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , # 10 p. 2293 - 2295
反应条件
1: (i) Et2O, (ii) EtMgBr, (iii) /BRN= 1209232/, THF, Et2O
2: NaOH / methanol; H2O
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
(i) Mg, Et2O, (ii) /BRN= 878156/; Multistep reaction;
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
1: 2-hydroxy-1,3-dimethylbenzene With sodium hydride in toluene
T=10 - 15°C; 0.75 h;
2: 1-chloro-3-methyl-2-butene in toluene
T=5 - 15°C; 3.5 h;
3: With hydrogen; palladium 10 on activated carbon in methanol; toluene
T=20 - 22°C; P=225.023 Torr;
参考文献
GIVAUDAN SA
Patent: WO2004/776 A1, 2003 ;
Location in patent: Page 9 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Matsushita,H.; Negishi,E.I.
Journal of the American Chemical Society, 1981 , vol. 103, p. 2882
反应条件
in tetrahydrofuran
24 h;
参考文献
Matsushita,H.; Negishi,E.I.
Journal of the American Chemical Society, 1981 , vol. 103, p. 2882
