1-氯-3-甲基-2-丁烯合成路线 （共 287 条）
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 878156/
2: (i) Cu2Br2, Et2O, (ii) /BRN= 1732380/, (iii) /BRN= 1900390/
3: LiAlH4 / diethyl ether
4: N-chloro-succinimide, Me2S
5: diethyl ether
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 878156/
2: (i) Cu2Br2, Et2O, (ii) /BRN= 1732380/, (iii) /BRN= 1900390/
3: LiAlH4 / diethyl ether
4: N-chloro-succinimide, Me2S
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 878156/
2: (i) Cu2Br2, Et2O, (ii) /BRN= 1732380/, (iii) /BRN= 1900390/
3: LiAlH4 / diethyl ether
4: N-chloro-succinimide, Me2S
5: (i) dioxane, Et2O, (ii) /BRN= 3660023/, (iii) /BRN= 1900390/
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 878156/
2: (i) Cu2Br2, Et2O, (ii) /BRN= 1732380/, (iii) /BRN= 1900390/
3: LiAlH4 / diethyl ether
4: N-chloro-succinimide, Me2S
5: (i) dioxane, Et2O, (ii) /BRN= 3660023/, (iii) /BRN= 1900390/
6: (i) aq. NaOH, HMPA, (ii) /BRN= 969135/
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 878156/
2: (i) Cu2Br2, Et2O, (ii) /BRN= 1732380/, (iii) /BRN= 1900390/
3: LiAlH4 / diethyl ether
View Scheme
参考文献
Chuit; Cahiez; Normant; Villieras
Tetrahedron, 1976 , vol. 32, # 14 p. 1675 - 1680
反应条件
sodium hydroxide; Aliquatreg; 336 in water; toluene
T=100°C; 4 h;
参考文献
International Flavors and Fragrances Inc.
Patent: US7141699 B1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
1: (i) nBuLi, (ii) /BRN= 878156/, (iii) aq. H2O2
2: (i) nBuLi, (ii) /BRN= 385735/
View Scheme
参考文献
Lythgoe,B. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 2386 - 2390
参考文献
Boord et al.
Industrial and Engineering Chemistry, 1949 , vol. 41, p. 615
反应条件
zinc in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Tokuda, Masao; Kurono, Nobuhito; Mimura, Nobuo
Chemistry Letters, 1996 , # 12 p. 1091 - 1092
反应条件
chloro-trimethyl-silane; zinc in tetrahydrofuran
T=50°C;
参考文献
Ishino, Yoshio; Mihara, Masatoshi; Kageyama, Manabu
Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6601 - 6604
