potassium carbonate in acetone 18 h; Reflux;

1.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 1.2: -78 - 25 °C / Inert atmosphere 2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 3.1: potassium carbonate / acetone / 18 h / Reflux 4.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 4.2: -78 - 25 °C / Inert atmosphere 5.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 6.1: potassium carbonate / acetone / 18 h / Reflux View Scheme

1.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 2.1: potassium carbonate / acetone / 18 h / Reflux 3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 3.2: -78 - 25 °C / Inert atmosphere 4.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 5.1: potassium carbonate / acetone / 18 h / Reflux View Scheme

1.1: potassium carbonate / acetone / 18 h / Reflux 2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 2.2: -78 - 25 °C / Inert atmosphere 3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 4.1: potassium carbonate / acetone / 18 h / Reflux View Scheme

1.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 1.2: -78 - 25 °C / Inert atmosphere 2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 3.1: potassium carbonate / acetone / 18 h / Reflux View Scheme

1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 2: potassium carbonate / acetone / 18 h / Reflux View Scheme

1.1: iodine cloride / tetrachloromethane / 12 h / 0 - 25 °C 2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 2.2: -78 - 25 °C / Inert atmosphere 3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 4.1: potassium carbonate / acetone / 18 h / Reflux 5.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere 5.2: -78 - 25 °C / Inert atmosphere 6.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere 7.1: potassium carbonate / acetone / 18 h / Reflux View Scheme

1: SnCl2*2H2O, HCl 2: (i) NaNO2, aq. HCl, AcOH, (ii) H3PO2 View Scheme

(i) NaNO2, aq. HCl, AcOH, (ii) H3PO2; Multistep reaction;