2-丁基-1,4-二氢-6-甲基-4-氧代-5-嘧啶乙酸乙酯合成路线 （共 4 条）
反应条件
1: lithium hydride / ethyl acetate; N,N-dimethyl-formamide 2: water; sodium hydroxide / methanol / 20 °C 3: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform 4: Lawesson's reagent / toluene / Reflux 5: hydrogenchloride; water / methanol / Reflux View Scheme
参考文献
Kim, Tae Woo; Yoo, Byoung Wook; Lee, Joon Kwang; Kim, Ji Han; Lee, Kyung-Tae; Chi, Yong Ha; Lee, Jae Yeol
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1649 - 1654
反应条件
1: lithium hydride / ethyl acetate; N,N-dimethyl-formamide
2: water; sodium hydroxide / methanol / 20 °C
3: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / chloroform
View Scheme
参考文献
Kim, Tae Woo; Yoo, Byoung Wook; Lee, Joon Kwang; Kim, Ji Han; Lee, Kyung-Tae; Chi, Yong Ha; Lee, Jae Yeol
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1649 - 1654
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: hydrogenchloride / methanol / 0 °C<br />2: sodium ethanolate / ethanol<br /> <br />
参考文献
Kim, Tae Woo; Yoo, Byoung Wook; Lee, Joon Kwang; Kim, Ji Han; Lee, Kyung-Tae; Chi, Yong Ha; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1649 - 1654
反应条件
Stage #1: <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3593646', constants.ctx, '0')">sodium ethanolate</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br /> <br />Stage #2: <b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3587154', constants.ctx, '0')">ammonia</a> <br /> <br />
参考文献
Kim, Tae Woo; Yoo, Byoung Wook; Lee, Joon Kwang; Kim, Ji Han; Lee, Kyung-Tae; Chi, Yong Ha; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1649 - 1654
