4-氯-3-甲酰基香豆素合成路线 （共 21 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0 - 50°C; 0.5 h; 2: 4-hydroxy-coumarin in N,N-dimethyl-formamide T=60°C; 12 h;
参考文献
Li, Kuan-Ting; Lin, Yong-Bo; Yang, Ding-Yah
Organic Letters, 2012 , vol. 14, # 5 p. 1190 - 1193
反应条件
trichlorophosphate in N,N-dimethyl-formamide T=-10 - 60°C;
参考文献
XTL BIOPHARMACEUTICALS, LTD.
Patent: WO2007/133211 A1, 2007 ;
Location in patent: Example 2 ;
反应条件
1: With trichlorophosphate T=-10 - 60°C; 3 h; 2: With water T=0°C;
参考文献
Steinfuehrer, Thorsten; Hantschmann, Achim; Pietsch, Michael; Weissenfels, Manfred
Liebigs Annalen der Chemie, 1992 , # 1 p. 23 - 28
反应条件
trichlorophosphate T=60 - 70°C; Vilsmeier-Haack reaction; 6 h;
参考文献
Bandyopadhyay, Chandrakanta; Ranabir Sur, Kumar; Patra, Ranjan; Sen, Arunabha
Tetrahedron, 2000 , vol. 56, # 22 p. 3583 - 3587
反应条件
trichlorophosphate T=50 - 55°C;
参考文献
Weissenfels, Manfred; Hantschmann, Achim; Steinfuehrer, Thorsten; Birkner, Eckhard
Zeitschrift fuer Chemie (Stuttgart, Germany), 1989 , vol. 29, # 5 p. 166
反应条件
1: pyridine / dichloromethane 2: AlCl3, aluminium chloride / 120 °C 3: sodium hydride 4: trichlorophosphate / 2.25 h / -10 - 60 °C View Scheme
参考文献
Qiang, Dong Zhi; Shi, Jing Bo; Song, Bao An; Liu, Xin Hua
RSC Advances, 2014 , vol. 4, # 11 p. 5607 - 5617
反应条件
1: Eaton’s reagent / 60 - 70 °C 2: trichlorophosphate / 50 - 60 °C View Scheme
参考文献
Qiang, Dong Zhi; Shi, Jing Bo; Song, Bao An; Liu, Xin Hua
RSC Advances, 2014 , vol. 4, # 11 p. 5607 - 5617
反应条件
trichlorophosphate T=35°C; 0.5 h; other carbonyl compounds; Product distributionMechanism;
参考文献
Rahman; Khan; Siddiqi; Zaman
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 10 p. 941 - 943
反应条件
1: AlCl3, aluminium chloride / 120 °C 2: sodium hydride 3: trichlorophosphate / 2.25 h / -10 - 60 °C View Scheme
参考文献
Kumar, J. Ashok; Saidachary; Mallesham; Sridhar; Jain, Nishant; Kalivendi, Shashi Vardhan; Rao, V. Jayathirtha; Raju, B. China
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 389 - 402
反应条件
1: sodium hydride 2: trichlorophosphate / 2.25 h / -10 - 60 °C View Scheme
参考文献
Kumar, J. Ashok; Saidachary; Mallesham; Sridhar; Jain, Nishant; Kalivendi, Shashi Vardhan; Rao, V. Jayathirtha; Raju, B. China
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 389 - 402
