4,4-二(4-氟苯基)丁烷-1-醇合成路线 （共 13 条）
反应条件
1: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C 2: 75 percent / Na2CO3; KI / toluene / Heating View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
Jone's reagent in acetone 0.5 h; Cooling with ice;
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
反应条件
1: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C 2: 70 percent / Na2CO3; KI / toluene / 66 h / Heating View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
hydrogen; 10 palladium on active carbon in ethanol
Heating;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 85 percent / diethyl ether; tetrahydrofuran / 5 h / Heating
2: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr
3: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
4: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 61 percent / PPh3; H2 / HRh(CO)(PPh3)3 / toluene / 24 h / 100 °C / 76000 Torr
2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr
2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
2: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
参考文献
Tai, Chih-Ho; Wu, Hsiao-Ching; Li, Wen-Ren
Organic Letters, 2004 , vol. 6, # 17 p. 2905 - 2908
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride
参考文献
Rajsner; Kopicova; Holubek; et al.
Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, # 7 p. 1760 - 1777
