5-溴-2-羟基-3-甲氧基苯甲醛合成路线 （共 25 条）
反应条件
1: 29 g / K2CO3 / acetone / 3 h / Heating
2: 1.) H2CO3H; 2.) 5 percent KOH / 1.) formic acid, overnight; 2.) ether, 2 h
3: dimethylformamide / 4 h / Heating
4: Raney-Ni / H2O; formic acid / 2 h / Heating
5: 1.) HCO3H; 2.) 5 percent KOH / 1.) formic acid; 2.) ether
6: 1.8 g / K2CO3 / dimethylformamide / 1 h / 120 °C / Heating
View Scheme
参考文献
Iinuma; Tanaka; Ito; Mizuno
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 660 - 667
反应条件
1: 29 g / K2CO3 / acetone / 3 h / Heating
2: 1.) H2CO3H; 2.) 5 percent KOH / 1.) formic acid, overnight; 2.) ether, 2 h
3: dimethylformamide / 4 h / Heating
4: Raney-Ni / H2O; formic acid / 2 h / Heating
5: 1.) HCO3H; 2.) 5 percent KOH / 1.) formic acid; 2.) ether
6: 1.8 g / K2CO3 / dimethylformamide / 1 h / 120 °C / Heating
7: 400 mg / POCl3 / Ambient temperature
View Scheme
参考文献
Iinuma; Tanaka; Ito; Mizuno
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 660 - 667
反应条件
boron tribromide in dichloromethane
T=-78 - 20°C; 6 h;
参考文献
Yamaguchi, Seiji; Tsuchida, Nao; Miyazawa, Masahiro; Hirai, Yoshiro
Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7505 - 7511
参考文献
Lin, Shun-Yu; Chen, Chih-Lung; Lee, Yean-Jang
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2968 - 2971
反应条件
sodium hydroxide; dihydrogen peroxide in water
0.5 h; Ambient temperature;
参考文献
Magnus, Philip; Sebhat, Iyassu K.
Tetrahedron, 1998 , vol. 54, # 51 p. 15509 - 15524
