3-甲酰基-4-氧代丁酸乙酯合成路线 （共 4 条）
反应条件
hydroxylamine hydrochloride in ethanol 2 h; Heating / reflux;
参考文献
AVEXA LIMITED
Patent: WO2007/124546 A1, 2007 ;
Location in patent: Page/Page column 61 ;
反应条件
1: formic acid ethyl ester With sodium hydride in diethyl ether
2: ethyl 3-ethoxy-3-methoxypropanoate in diethyl ether
T=0 - 25°C; 17 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71963 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/071963 A2
反应条件
sodium
T=0 - 20°C; 48 h;
参考文献
AVEXA LIMITED
Patent: WO2007/124546 A1, 2007 ;
Location in patent: Page/Page column 61 ;
反应条件
triethylamine in ethanol
T=25°C; 12 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71963 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/071963 A2
