N-ethyl-N,N-diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in 1,2-dichloro-ethane T=80°C; 5 h;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />1.2: 69 percent / CuCl / hexane; tetrahydrofuran / 0.5 h / -78 &deg;C<br />2.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />2.2: 89 percent / hexane; tetrahydrofuran / 0.25 h / -78 &deg;C<br />3.1: LiHMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />3.2: 94 percent / hexane; tetrahydrofuran / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />1.2: 89 percent / hexane; tetrahydrofuran / 0.25 h / -78 &deg;C<br />2.1: LiHMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />2.2: 94 percent / hexane; tetrahydrofuran / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: BuLi / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />1.2: 89 percent / hexane; tetrahydrofuran / 0.25 h / -78 &deg;C<br />2.1: LiHMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 20 &deg;C<br />2.2: 94 percent / hexane; tetrahydrofuran / -78 - 20 &deg;C<br /> <br /> &nbsp;