1-(3-氨基丙基)咪唑合成路线 （共 13 条）
反应条件
hydrazine in ethanol 16 h; Heating;
参考文献
Bergstrom, Carl P.; Sloan, Charles P.; Lau, Wai-Yu; Smith, David W.; Zheng, Ming; Hansel, Steven B.; Polson, Craig T.; Corsa, Jason A.; Barten, Donna M.; Felsenstein, Kevin M.; Roberts, Susan B.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 464 - 468
反应条件
nickel monoaluminide in tetrahydrofuran; methanol; toluene
参考文献
American Cyanamid Company
Patent: US4555519 A1, 1985 ;
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
1: 60 percent / dimethylsulfoxide 2: 20 h / 120 - 130 °C View Scheme
参考文献
Wright Jr.; Tomcufcik; Chan; Marisco; Press
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2277 - 2283
反应条件
1: With 3 A molecular sieve; sodium acetate in methanol T=20°C; 2: With sodium tetrahydroborate in methanol T=0 - 20°C; 4 h;
参考文献
Roman, Gheorghe
Journal of the Serbian Chemical Society, 2012 , vol. 77, # 2 p. 131 - 140
参考文献
American Cyanamid Company
Patent: US4684654 A1, 1987 ;
反应条件
toluene-4-sulfonic acid in toluene
4 h; Reflux;
参考文献
Ryabukhin, Sergey V.; Panov, Dmitriy M.; Granat, Dmitry S.; Ostapchuk, Eugeniy N.; Kryvoruchko, Dmitriy V.; Grygorenko, Oleksandr O.
ACS Combinatorial Science, 2014 , vol. 16, # 3 p. 146 - 153
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=23°C; 6 h;
参考文献
Wyeth
Patent: US2008/287452 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
in ethanol
4 h; Ambient temperature;
参考文献
Wright Jr.; Tomcufcik; Chan; Marisco; Press
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2277 - 2283
反应条件
in toluene
T=90 - 95°C;
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
