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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
50361-53-0
合成路线
(共 25 条)
50361-53-0
→
反应条件
132205-64-2
反应条件
1: pyridine; trichlorophosphate / benzene / 3 h / |Reflux; |Schlenk technique 2: sodium tetrahydroborate / ethanol / 12 h / 20 °C / |Reflux; |Schlenk technique View Scheme
参考文献
Mo, Dong-Liang; Ding, Chang-Hua; Dai, Li-Xin; Hou, Xue-Long
Chemistry - An Asian Journal, 2011 , vol. 6, # 12 p. 3200 - 3204
50361-53-0
→
反应条件
91245-72-6
1,2,3,4-四氢-1-萘甲胺
反应条件
1: LiAlH4 / tetrahydrofuran / 3 h / Heating 2: 85 percent / H2, HCl / 10percent Pd/C / methanol View Scheme
参考文献
Trivedi, B. K.; Blankley, C. J.; Bristol, J. A.; Hamilton, H. W.; Patt, W. C.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1043 - 1049
50361-53-0
→
反应条件
1092080-61-9
+
1335545-22-6
+
529-34-0
1-四氢萘酮
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 3: immobilized Pseudomonas cepacia lipase; water / 1,4-dioxane / 156 h / 30 °C / Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1335545-25-9
+
529-34-0
1-四氢萘酮
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 3: immobilized Candida antarctica lipase A; water / 1,4-dioxane / 5 h / 40 °C / pH 5 / Citrate buffer; Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1335545-31-7
+
529-34-0
1-四氢萘酮
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere 3: immobilized Candida antarctica lipase A; 1,2,3,4-tetrahydro-1-naphthylamine / diethyl ether / 23 h / 30 °C / Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1335545-25-9
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 3: immobilized Pseudomonas cepacia lipase; water / 1,4-dioxane / 30 °C / pH 5 / Citrate buffer; Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1335545-31-7
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere 3: immobilized Pseudomonas cepacia lipase; water / 1,4-dioxane / 312 h / 30 °C / pH 5 / Citrate buffer; Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1335545-31-7
+
529-34-0
1-四氢萘酮
反应条件
1.1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2.1: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere 3.1: immobilized Pseudomonas cepacia lipase; water / diethyl ether / 16 h / 30 °C / Enzymatic reaction 3.2: 6 h / 20 °C View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
529-34-0
1-四氢萘酮
反应条件
1.1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2.1: pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere 3.1: immobilized Pseudomonas cepacia lipase; water / 1,4-dioxane / 156 h / 30 °C / Enzymatic reaction 3.2: 6 h / 20 °C View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
50361-53-0
→
反应条件
1092080-61-9
+
1335545-22-6
+
1335545-31-7
+
529-34-0
1-四氢萘酮
反应条件
1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere 3: immobilized Candida antarctica lipase A; water / diethyl ether / 2 h / 30 °C / Enzymatic reaction View Scheme
参考文献
Rodriguez-Rodriguez, Jesus A.; Gotor, Vicente; Brieva, Rosario
Tetrahedron Asymmetry, 2011 , vol. 22, # 11 p. 1218 - 1224
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