1-氨基甲基-1,2,3,4-四氢-萘-1-醇合成路线 （共 5 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
参考文献
Trivedi, B. K.; Blankley, C. J.; Bristol, J. A.; Hamilton, H. W.; Patt, W. C.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1043 - 1049
参考文献
Abbott Laboratories
Patent: US5158948 A1, 1992 ;
US 5158948 A
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
3 h; Heating; Yield given;
参考文献
Trivedi, B. K.; Blankley, C. J.; Bristol, J. A.; Hamilton, H. W.; Patt, W. C.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1043 - 1049
反应条件
1: AlCl3 / 18 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Trivedi, B. K.; Blankley, C. J.; Bristol, J. A.; Hamilton, H. W.; Patt, W. C.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1043 - 1049
反应条件
lithium aluminium tetrahydride; zinc(II) iodide
1.) 0 deg C, several days. 2.) THF, 3h, reflux.; Yield given. Multistep reaction;
参考文献
Campbell, Malcolm M.; Abbas, Nabeeha; Sainsbury, Malcolm
Tetrahedron, 1985 , vol. 41, # 23 p. 5637 - 5644
