4,5,6,7-四氢-1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代-1-哌啶基)苯基]-1H-吡唑并[3,4-c]吡啶-3-羧酸乙酯合成路线 (共 16 条)
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in toluene 48 h; Inert atmosphereReflux;
参考文献
WO2012/168364 A1, ;
Page/Page column 18-19 ;
反应条件
in water; isopropyl alcohol T=50 - 55°C;
参考文献
WO2014/72884 A1, ;
Page/Page column 10 ;
反应条件
hydrogenchloride; triethylamine in ethyl acetate
反应条件
1: With triethylamine; potassium iodide in ethyl acetate 6 h; Reflux; 2: With hydrogenchloride in water; ethyl acetate T=0 - 20°C;
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
in tetrahydrofuran; ethanol Inert atmosphereAlkaline conditions;
参考文献
WO2013/119328 A1, ;
Paragraph 0033; 0034; 0035 ;
反应条件
1.1: hydrogenchloride; sodium nitrite / water / -5 - 0 °C 1.2: 0 - 20 °C 2.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 2.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: triethylamine / ethyl acetate / 0 °C / Inert atmosphere; Reflux 1.2: 0 - 20 °C 2.1: potassium phosphate; N-methyl-2-(methylamino)ethylamine / copper(l) iodide / toluene / 48 h / Inert atmosphere; Reflux View Scheme
反应条件
1.1: triethylamine / ethyl acetate / 0 °C / Inert atmosphere; Reflux 1.2: 0 - 20 °C 2.1: potassium phosphate; N-methyl-2-(methylamino)ethylamine / copper(l) iodide / toluene / 48 h / Inert atmosphere; Reflux View Scheme
反应条件
1.1: triethylamine / toluene / 0 - 50 °C / Inert atmosphere 2.1: triethylamine / ethyl acetate / 0 °C / Inert atmosphere; Reflux 2.2: 0 - 20 °C 3.1: potassium phosphate; N-methyl-2-(methylamino)ethylamine / copper(l) iodide / toluene / 48 h / Inert atmosphere; Reflux View Scheme
反应条件
1.1: pyridine / 3 h / 25 - 30 °C 1.2: 1 h 2.1: isopropyl alcohol; water / 50 - 55 °C View Scheme