4,5,6,7-四氢-1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代-1-哌啶基)苯基]-1H-吡唑并[3,4-c]吡啶-3-羧酸乙酯合成路线 （共 16 条）
反应条件
1.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 3.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 3.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere 3.1: phosphorus pentachloride / chloroform / |Reflux 4.1: 1 h / |Reflux 5.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 6.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 7.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 8.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 8.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: triethylamine / tetrahydrofuran / 5 h / 5 - 20 °C / |Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere 3.1: phosphorus pentachloride / chloroform / |Reflux 4.1: 1 h / |Reflux 5.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 6.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 7.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 8.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 8.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 5 - 20 °C / |Inert atmosphere 2.1: phosphorus pentachloride / chloroform / |Reflux 3.1: 1 h / |Reflux 4.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 5.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 6.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 7.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 7.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: phosphorus pentachloride / chloroform / |Reflux 2.1: 1 h / |Reflux 3.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 4.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 6.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 6.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
反应条件
1.1: water; Na2S*9H2O / ethanol / 4 h / 50 °C 2.1: triethylamine / tetrahydrofuran / 2 h / 5 - 50 °C / |Inert atmosphere 3.1: potassium tert-butylate / tetrahydrofuran / 8.5 h / 5 - 50 °C / |Inert atmosphere 4.1: potassium iodide; triethylamine / ethyl acetate / 6 h / |Reflux 4.2: 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 1 p. 72 - 79
