2-溴-3,3-二甲基丁酸合成路线 （共 10 条）
反应条件
bromine in methanol; water
反应条件
(NH4)2S; sulfur in pyridine T=180°C;
参考文献
Feichtinger,H.
Chemische Berichte, 1962 , vol. 95, p. 2238 - 2242
反应条件
1: With methanesulfonic acid; zinc in tetrahydrofuran Heating / reflux; 2: 2-bromo-2-tert-butyl acetic acid; (S)-4-chloro-3-trimethylsilyloxybutyronitrile in tetrahydrofuran 1.5 h; Heating / reflux; 3: With hydrogenchloride in tetrahydrofuran; water pH=4; 3 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2004/63132 A1, 2004 ;
Location in patent: Page 6-7 ;
参考文献
Canceill,J. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 2653 - 2658
反应条件
bromine; phosphorus trichoride
T=60 - 70°C; dann auf 100grad;
参考文献
Mallinckrodt Chem.Works
Patent: US2135064 , 1936 ;
Full Text Show Details
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
1: Cr2O3-H2SO4
2: NaOBr
3: PCl3; bromine / 60 - 70 °C / dann auf 100grad
View Scheme
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
1: NaOBr
2: PCl3; bromine / 60 - 70 °C / dann auf 100grad
View Scheme
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
Yield given. Multistep reaction;
参考文献
Duhamel, Lucette; Plaquevent, Jean-Christophe
Bulletin de la Societe Chimique de France, 1982 , vol. 2, # 1-2 p. 69 - 74
反应条件
1: SOCl2
2: (i), (ii) aq. HCl
3: acetic acid
View Scheme
参考文献
Gladiali,S. et al.
Gazzetta Chimica Italiana, 1977 , vol. 107, p. 293 - 298
参考文献
Gripenberg; Silander
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 383,384,385,388
