5,8-二甲基-1-四酮合成路线 （共 25 条）
反应条件
sulfuric acid in neat (no solvent)
T=90°C; 1 h;
参考文献
Khalaf, Ali A.; Abdel-Wahab, Aboel-Magd A.; El-Khawaga, Ahmed M.; El-Zohry, Maher F.
Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 7-8 p. 285 - 291
反应条件
aluminium trichloride
T=75°C; 20 h;
参考文献
Jung; Koreeda
Journal of Organic Chemistry, 1989 , vol. 54, # 24 p. 5667 - 5675
反应条件
1: 94 percent / 80percent N2H4*H2O, KOH / various solvent(s) / 1) 2 h, reflux, 2) 180-190 deg C, ca. 4 h
2: 68 percent / 80percent H2SO4 / 2 h / 100 °C
View Scheme
参考文献
Boberg, Friedrich; Jachiewicz, Adam; Garming, Alfons
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 72, # 1-4 p. 1 - 12
反应条件
aluminium trichloride
T=90°C; Alkylation; Friedel-Crafts reaction; 6 h;
参考文献
Mane, Ramchandra Bhimrao; Kadam, Abhijit Jaysingrao
Collection of Czechoslovak Chemical Communications, 1999 , vol. 64, # 3 p. 533 - 538
反应条件
1: 92 percent / AlCl3 / 3 h / 20 - 50 °C
2: 96 percent / H3PO4 / 2 h / 100 - 110 °C
View Scheme
参考文献
Banerjee, Ajoy K.; Vera, William; Laya, Manuel S.
Synthetic Communications, 2004 , vol. 34, # 12 p. 2301 - 2308
反应条件
bis(acetylacetonate)nickel(II); trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; phenol
1.) THF, hexane, RT, 2 h, 2.) THF, hexane, overnight; Yield givenMultistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mori, Naoyoshi; Ikeda, Shin-Ichi; Sato, Yoshiro
Journal of the American Chemical Society, 1999 , vol. 121, # 12 p. 2722 - 2727
反应条件
bis(acetylacetonate)nickel(II); air; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; phenol
1.) hexane, THF, room temperature, 2 h, 2.) overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ikeda; Mori; Sato
Journal of the American Chemical Society, 1997 , vol. 119, # 20 p. 4779 - 4780
反应条件
aluminium trichloride; sulfuric acid
1.) CS2, 3 h, 25 deg C; 2.) neat, 1 h, 90 deg C;
参考文献
Khalaf, Ali A.; Abdel-Wahab, Aboel-Magd A.; El-Khawaga, Ahmed M.; El-Zohry, Maher F.
Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 7-8 p. 285 - 291
参考文献
Von Doering, William E.; Keliher, Edmund J.
Journal of the American Chemical Society, 2007 , vol. 129, # 9 p. 2488 - 2495
反应条件
1: (i) (saponification), (ii) Zn, aq. HCl
2: (i) SOCl2, (ii) SnCl4, CS2
View Scheme
参考文献
Legros,R.; Cagniant,P.
Bulletin de la Societe Chimique de France, 1961 , p. 1626 - 1627
