2,2,2-三氯-1-(4,5-二溴-1H-吡咯-2-基)-1-乙酮合成路线 (共 9 条)
反应条件
bromine; acetic acid 27 h;
参考文献
White, Alex W.; Carpenter, Nicholas; Lottin, Jerome R. P.; McClelland, Richard A.; Nicholson, Robert I.
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 246 - 253,8
反应条件
bromine in chloroform T=0°C; 4.5 h;
参考文献
Keifer, Paul A.; Schwartz, Robert E.; Koker, Moustapha E. S.; Hughes, Robert G.; Rittschof, Dan; Rinehart, Kenneth L.
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 2965 - 2975
反应条件
in bromine; acetic acid
参考文献
Sterling Drug Inc.
Patent: US4000160 A1, 1976 ;
反应条件
sodium hydroxide Hydrolysis; 0.583333 h;
参考文献
Lindel, Thomas; Hoffmann, Holger; Hochguertel, Matthias; Pawlik, Joseph R.
Journal of Chemical Ecology, 2000 , vol. 26, # 6 p. 1477 - 1496
反应条件
hydrazine hydrate in N-methyl-acetamide; water
参考文献
Rane, Rajesh A.; Gutte, Shweta D.; Sahu, Niteshkumar U.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6429 - 6432
反应条件
in chloroform 0.5 h; Yield given;
参考文献
Keifer, Paul A.; Schwartz, Robert E.; Koker, Moustapha E. S.; Hughes, Robert G.; Rittschof, Dan; Rinehart, Kenneth L.
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 2965 - 2975
反应条件
1: 79 percent / Na2CO3 / dimethylformamide / 20 °C 2: 92 percent / aq. HCl / ethanol / 1 h / 20 °C View Scheme
参考文献
Ando, Naoki; Terashima, Shiro
Synlett, 2006 , # 17 p. 2836 - 2840
反应条件
ammonium hydroxide Substitution; 0.75 h;
参考文献
Lindel, Thomas; Hoffmann, Holger; Hochguertel, Matthias; Pawlik, Joseph R.
Journal of Chemical Ecology, 2000 , vol. 26, # 6 p. 1477 - 1496
反应条件
1: acetonitrile 2: methanesulfonic acid / 120 h / 23 °C View Scheme
参考文献
Xu, Ying-Zi; Phan, Giao; Yakushijin, Kenichi; Home, David A.
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 351 - 354