N-[4-(羟基乙氧基)苯基]乙酰胺合成路线 （共 10 条）
反应条件
sodium methylate; acetic acid in ethyl acetate
参考文献
ICI Australia Limited
Patent: US4460588 A1, 1984 ;
反应条件
sodium hypophosphite; palladium on activated charcoal in tetrahydrofuran; water T=50°C; 6 h;
参考文献
Sala, Roberto; Doria, Gianfederico; Passarotti, Carlo
Tetrahedron Letters, 1984 , vol. 25, # 40 p. 4565 - 4568
反应条件
sodium hydroxide T=60 - 70°C; 8 h;
参考文献
Villa, Stefania; Barlocco, Daniela; Cignarella, Giorgio; Papp, Gyula Julius; Balati, Beata; Takacs, Janos; Varro, Andras; Borosy, Andras; Keseru, Katalin; Matyus, Peter
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 495 - 506
反应条件
boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene T=20°C; 2 h; regioselective reaction;
参考文献
Liu, Huan; Wang, Xuemin; Gu, Yonghong
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1614 - 1620
反应条件
potassium hydroxide in water 3 h; Heating;
参考文献
Litak, Peter T.; Kauffman, Joel M.
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 2 p. 457 - 480
反应条件
1: SOCl2 / CHCl3; dimethylformamide / 2.5 h / Heating 2: 10.1 g / aq. HCl / 0.5 h / Heating View Scheme
参考文献
The Boots Company
Patent: US3957999 A1, 1976 ;
参考文献
Villa, Stefania; Barlocco, Daniela; Cignarella, Giorgio; Papp, Gyula Julius; Balati, Beata; Takacs, Janos; Varro, Andras; Borosy, Andras; Keseru, Katalin; Matyus, Peter
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 495 - 506
参考文献
Katrak
Journal of the Indian Chemical Society, 1936 , vol. 13, p. 334
反应条件
sulfuric acid
2 h; Heating;
参考文献
Litak, Peter T.; Kauffman, Joel M.
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 2 p. 457 - 480
反应条件
1: SOCl2
2: toluene
3: aqueous hydrochloric acid
View Scheme
参考文献
Herbst; Simonian
Journal of Organic Chemistry, 1952 , vol. 17, p. 595,598
