1.1: EDCI; DMAP / CH2Cl2 / 0 - 20 °C 2.1: 78 percent / second generation Grubbs' catalyst / toluene / 110 °C 3.1: KHMDS / tetrahydrofuran; toluene / 0 °C 3.2: 76 percent / tetrahydrofuran; toluene / -78 - -20 °C 4.1: 97 percent / HF*pyridine / tetrahydrofuran / 3 h / 20 °C 5.1: 24 percent / dimethyldioxirane / CH2Cl2; acetone / 2.7 h / -50 °C 6.1: 71 percent / TrisNHNH2; Et3N / 1,2-dichloro-ethane / 6 h / 50 °C View Scheme

1.1: EDCI; DMAP / CH2Cl2 / 0 - 20 °C 2.1: 78 percent / second generation Grubbs' catalyst / toluene / 110 °C 3.1: KHMDS / tetrahydrofuran; toluene / 0 °C 3.2: 76 percent / tetrahydrofuran; toluene / -78 - -20 °C 4.1: 97 percent / HF*pyridine / tetrahydrofuran / 3 h / 20 °C 5.1: 91 percent / TrisNHNH2; Et3N / 1,2-dichloro-ethane / 7 h / 50 °C View Scheme