2,4-二甲基-5-噻唑乙腈合成路线 (共 11 条)
反应条件
methanol; nickel Hydrogenation;
参考文献
Burger; Ullyot
Journal of Organic Chemistry, 1947 , vol. 12, p. 342,351
反应条件
1: LiAlH4 / diethyl ether / Heating
2: (i) SOCl2, CHCl3, (ii) /BRN= 3587243/, DMSO
View Scheme
参考文献
Hatanaka,M.; Ishimaru,T.
Journal of Medicinal Chemistry, 1973 , vol. 16, p. 978 - 984
参考文献
Gregory; Wiggins
Journal of the Chemical Society, 1947 , p. 1400,1402
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Burger; Ullyot
Journal of Organic Chemistry, 1947 , vol. 12, p. 342,351
反应条件
1: aqueous NH3
2: POCl3
View Scheme
参考文献
Gregory; Wiggins
Journal of the Chemical Society, 1947 , p. 1400,1402
Full Text Show Details
Burger; Ullyot
Journal of Organic Chemistry, 1947 , vol. 12, p. 342,351
反应条件
2: aqueous NH3
3: POCl3
View Scheme
参考文献
Gregory; Wiggins
Journal of the Chemical Society, 1947 , p. 1400,1402
反应条件
(i) SOCl2, CHCl3, (ii) /BRN= 3587243/, DMSO; Multistep reaction;
参考文献
Hatanaka,M.; Ishimaru,T.
Journal of Medicinal Chemistry, 1973 , vol. 16, p. 978 - 984
反应条件
hydrogenchloride; boron trifluoride diethyl etherate
参考文献
Khilya,V.P. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 8 p. 1059 - 1062
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 8 p. 74 - 98
反应条件
hydrogenchloride; boron trifluoride diethyl etherate
参考文献
Khilya,V.P. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 8 p. 1059 - 1062
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 8 p. 74 - 98
反应条件
1: BF3-Et2O, HCl
2: piperidine / pyridine
View Scheme
参考文献
Khilya,V.P. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 8 p. 1059 - 1062
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 8 p. 74 - 98
反应条件
1: BF3-Et2O, HCl
2: piperidine / pyridine
3: K2CO3 / acetone
View Scheme
参考文献
Khilya,V.P. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 8 p. 1059 - 1062
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 8 p. 74 - 98