carbon monoxide; tri-ruthenium(0)dodecacarbonyl in toluene T=220°C; P=60800 Torr; 5 h;

Rh6(CO)12 in toluene T=220°C; P=60800 Torr; 5 h;

acetic anhydride 27 h; Inert atmosphereReflux;

1.1: acetone / 18 h / Inert atmosphere; Reflux 2.1: hydrogen / palladium 10 on activated carbon / methanol 3.1: sodium hydroxide / ethyl acetate; water 3.2: 20 °C 4.1: sodium hydrogencarbonate / ethyl acetate; water 4.2: 14 h / Reflux View Scheme